Differential TLR activation of murine mesenchymal stem cells generates distinct immunomodulatory effects in EAE.

Stem Cell Res Ther. 2016 Oct 10;7(1):150.

Background: Recently, it has been observed that mesenchymal stem cells (MSCs) can modulate their immunoregulatory properties depending on the specific in-vitro activation of different Toll-like receptors (TLR), such as TLR3 and TLR4. In the present study, we evaluated the effect of polyinosinic:polycytidylic acid (poly(I:C)) and lipopolysaccharide (LPS) pretreatment on the immunological capacity of MSCs in vitro and in vivo.